Role of multimeric forms of adiponectin in metabolic disorders
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- DOI: https://doi.org/10.15562/diabesity.2015.10 |
- Published: 2015-01-15
Open Access & Peer Reviewed
Journal of Diabetes, Obesity and Metabolism
Journal of Diabetes, Obesity and Metabolism
Abstract
Adiponectin, also called Acrp30, is a 30-kDa protein that circulates in the blood at high levels (2-10 µg/ml in human) and constitutes 0.01% of the total plasma protein. In contrast to other adipokines such as leptin, adiponectin is believed to be an anti-inflammatory and insulin-sensitizing hormone whose levels are reduced in obesity. Adiponectin can exist in the blood as a trimer, with the potential to associate into hexamers and ï¬nally into multimers of high molecular weight (HMW) species. Adiponectin primarily mediates its insulin-sensitizing effects through various signaling proteins including the activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK). Recent reports suggest the anti-inflammatory and cytoprotective effects of adiponectin are mediated by direct activation of PI3K-Akt pathway. Interestingly adiponectin is also reported to decrease body weight by centrally mediated stimulation of energy expenditure
How to Cite
Kandasamy, A. D. (2015). Role of multimeric forms of adiponectin in metabolic disorders. Diabesity - Journal of Diabetes, Obesity and Metabolism, 1(1), 13–14. https://doi.org/10.15562/diabesity.2015.10
