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Matrix metalloproteinases and the vascular smooth muscle cell migration in hypertension

Vanessa de Almeida Belo, Michele Castro

Vanessa de Almeida Belo
Department of Pharmacology, Faculty of Medicine, University of Sao Paulo, Av. Bandeirantes, 3900 4049-900 Ribeirao Preto, SP, Brazil

Michele Castro
Department of Pharmacology, Faculty of Medicine, University of Sao Paulo, Av. Bandeirantes, 3900 4049-900 Ribeirao Preto, SP, Brazil. Email: castro@fmrp.usp.br
Online First: March 01, 2015 | Cite this Article
Belo, V., Castro, M. 2015. Matrix metalloproteinases and the vascular smooth muscle cell migration in hypertension. Diabesity 1(2): 15-17. DOI:10.15562/diabesity.2015.12


Vascular smooth muscle cells (VSMC) migration and proliferation may be the main precursors of the chronic and maladaptive vascular remodeling in hypertension. The proteolysis of extracellular matrix and the phenotype switch of VSMC need to occur in order to allow VSMC migration and the vascular remodeling and hypertrophy. The matrix metalloproteinases (MMPs) are well known to degrade many extracellular matrix and non-extracellular matrix components to favor VSMC migration and their phenotype switch. Targeting MMPs may reduce VSMC migration and the arterial maladaptation caused by hypertension and its cardiovascular events.
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