Endoplasmic reticulum stress in the pathogenesis of diabetes

Toru Hosoi , Koichiro Ozawa

Toru Hosoi
Hiroshima University. Email:

Koichiro Ozawa
Hiroshima University
Online First: October 15, 2015 | Cite this Article
Hosoi, T., Ozawa, K. 2015. Endoplasmic reticulum stress in the pathogenesis of diabetes. Diabesity 1(4): 31-33. DOI:10.15562/diabesity.2015.17

The accumulation of unfolded protein in the endoplasmic reticulum (ER) causes ER stress. Cells activate unfolded protein responses (UPR) to cope with such a stressful situation. Increasing evidence suggests that ER stress is involved in the pathogenesis of diabetes, especially insulin resistance and the impairment of insulin secretion. In addition, several UPR components have been suggested to play a key role in diabetes. In the present review, we summarize and discuss recent knowledge of ER stress regarding the pathogenesis of diabetes.
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