COMMENTARY

The enigma of uric acid in metabolic syndrome

Narasimman Gurusamy , Sivakumar Vijayaraghavalu, Adel Alhazzani, Harish Chandramoorthy

Narasimman Gurusamy
Department of Pharmacology, College of Pharmacy, King Khalid University, Abha - 61441, Kingdom of Saudi Arabia.. Email: ngurusamy@kku.edu.sa

Sivakumar Vijayaraghavalu
Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha 61441, Kingdom of Saudi Arabia

Adel Alhazzani
Department of Medicine, College of Medicine, King Khalid University, Abha, 61421, Kingdom of Saudi Arabia

Harish Chandramoorthy
Department of Microbiology & Parasitology, College of Medicine, King Khalid University, Abha, 61421, Kingdom of Saudi Arabia
Online First: September 15, 2015 | Cite this Article
Gurusamy, N., Vijayaraghavalu, S., Alhazzani, A., Chandramoorthy, H. 2015. The enigma of uric acid in metabolic syndrome. Diabesity 1(3): 29-30. DOI:10.15562/diabesity.2015.18


Metabolic syndrome is a group of risk factors including an increased level of triglycerides, fasting blood glucose, blood pressure or waist circumference, and or a decreased level of HDL cholesterol. The level of uric acid in the blood has been associated with the presence of metabolic syndrome, which can aggravate the prognosis of cardiovascular diseases, type 2 diabetes mellitus and stroke. On the interest to identify the early biomarkers of metabolic syndrome, Popovic et al involved 1333 patients and showed using logistic regression that a significant association between the blood levels of uric acid in the subjects diagnosed with metabolic syndrome and in the group of obese patients, who had the body mass index of more than 30 kg/m2. This study shed some light in identifying a metabolically unhealthy phenotype.
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