Insulin resistance (IR), short of diabetes mellitus, negatively impacts retinal vessel health. The purpose of this study was to evaluate the correlation between the number of sub-clinical retinal micro-aneurysms (MA#) identifiable by highly sensitive 580 nm multi-spectral retinal imaging (MSI 580 nm) and serological and calculated IR measures. Thirty (n=19 M; n=11 F) non-diabetic optometrists (n=54 eyes), 53.5 Â± 7.6 years, were imaged at a professional conference using multispectral imaging (MSI) of the retina (RHATM, Annidis Corporation, Ottawa, Canada). A six parameter blood panel requisition: fasting glucose (FBS), 2 hr glucose (GTT) tolerance, HbA1c, fasting insulin, 2 hr insulin and 25 OH vitamin D liver reserve status were provided to each participant. MSI retinal images were reviewed and the MA# in the central 30 degrees were counted. The calculated clinical parameters used to diagnose IR were most highly correlated with retinal MA#, specifically insulin sensitivity. Subclinical MA#, less visible to non-spectral cameras but observed with multispectral imaging, correlate with insulin, pancreatic function and calculated measures of IR, more closely than FBS and vitamin D status. Future diabetes intervention research should focus upon MSI MA# and IR as actionable pre-diabetes and pre-retinopathy risk factors.
Gelb, K., Richer, S., Zimmer, C. N., Sherman, J., & Gold, J. (2016). Retinal multispectral imaging of â€˜sub-clinicalâ€™ capillary micro-aneurysms in non-diabetics correlates with insulin resistance. Diabesity - Journal of Diabetes, Obesity and Metabolism, 2(3), 19–25. https://doi.org/10.15562/diabesity.2016.27