Retinal multispectral imaging of ‘sub-clinical’ capillary micro-aneurysms in non-diabetics correlates with insulin resistance

Kerry Gelb, Stuart Richer, Cheryl N Zimmer , Jerome Sherman, Jeffrey Gold

Kerry Gelb
161 Woodbridge Center Dr, Woodbridge, NJ, USA 07095

Stuart Richer
Eye Clinic, Captain James A Lovell FHCC 3001 Green Bay Rd, North Chicago, IL, USA 60064

Cheryl N Zimmer
Annidis Corporation. Email: cherylz@annidis.com

Jerome Sherman
SUNY College of Optometry 33 West 42nd Street New York, NY, USA 10036

Jeffrey Gold
Suburban Heart Group PA 1000 Galloping Hill Rd Ste 107, Union, NJ, USA 07083
Online First: July 15, 2016 | Cite this Article
Gelb, K., Richer, S., Zimmer, C., Sherman, J., Gold, J. 2016. Retinal multispectral imaging of ‘sub-clinical’ capillary micro-aneurysms in non-diabetics correlates with insulin resistance. Diabesity 2(3): 19-25. DOI:10.15562/diabesity.2016.27

Insulin resistance (IR), short of diabetes mellitus, negatively impacts retinal vessel health. The purpose of this study was to evaluate the correlation between the number of sub-clinical retinal micro-aneurysms (MA#) identifiable by highly sensitive 580 nm multi-spectral retinal imaging (MSI 580 nm) and serological and calculated IR measures. Thirty (n=19 M; n=11 F) non-diabetic optometrists (n=54 eyes), 53.5 ± 7.6 years, were imaged at a professional conference using multispectral imaging (MSI) of the retina (RHATM, Annidis Corporation, Ottawa, Canada). A six parameter blood panel requisition: fasting glucose (FBS), 2 hr glucose (GTT) tolerance, HbA1c, fasting insulin, 2 hr insulin and 25 OH vitamin D liver reserve status were provided to each participant. MSI retinal images were reviewed and the MA# in the central 30 degrees were counted. The calculated clinical parameters used to diagnose IR were most highly correlated with retinal MA#, specifically insulin sensitivity. Subclinical MA#, less visible to non-spectral cameras but observed with multispectral imaging, correlate with insulin, pancreatic function and calculated measures of IR, more closely than FBS and vitamin D status. Future diabetes intervention research should focus upon MSI MA# and IR as actionable pre-diabetes and pre-retinopathy risk factors.
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