Function and dysfunction of fatty acid mobilization: a review.
Joslyn K Beard, Dustin T Yates
Western populations have a growing obesity epidemic due in part to excessive nutrient intake from high-fat diets, which are increasingly common. Overindulgence of nutrients is associated with a greater incidence of metabolic dysfunction and a greater risk for obesity, diabetes, hypertension, and other metabolic disorders that lower quality of life. Research in humans and animal models has improved our understanding of how excess circulating free fatty acids negatively impact the ability of muscle and other tissues to regulate nutrient uptake and utilization. It is generally accepted by the scientific community that excess circulating fatty acids lead to insulin resistance, but there is little clarity regarding the underlying mechanisms. In the present review, we will outline the current understanding of the characteristics associated with fatty acid mobilization and fatty acid utilization within specific tissues. We will also discuss the potential mechanistic role of hyperlipidemia on metabolic dysfunction associated with type 2 diabetes.
METABOLIC SYNDROME AND REPRODUCTION: CURRENT PERSPECTIVES IN NIGERIA
Olulope Ajayi, Mabel Charles-Davies
Metabolic syndrome (MS) is a clustering of cardiovascular disease risk factors. It is a major health challenge globally, with an increased prevalence in the developing world. Studies on its role on reproduction in Nigeria are currently sparse. This article therefore, examines current knowledge on metabolic syndrome and reproduction in Nigerians. Academic databases including PubMed as well as Google search engine were searched between 2012 and 2019 for metabolic syndrome in reproduction in Nigerian males and females. Current observations suggest that metabolic syndrome adversely affects reproduction.